Mast Cells - Dr T C Theoharides MD PhD

The miraclesof science

After a spending 40 years at Tufts University, Dr. Theoharides assumed a new position on July 1 as Professor at the Institute of Neuro-Immune Medicine at Nova Southeastern Univesrity in Clearwater, FL.

APRIL IS AUTISM AWARENESS MONTH

See contributions by Dr. Theoharides

1. Autism Parenting Summit Lecture:
How Inflammation Alters the Fear Center in the Brain and Affects Behavior in Autism

Website / PDF

2. TACA conference on April 8-9 Lecture:

Your brain in autism and the spectrum of mast cell activation: from histamine intolerance to mastocytosis and everything in between.

Website / PDF

Increase in autism reported by the CDC

The Centers for Disease Control (CDC) published in Morbidity and Mortality Weekly Report, its findings from the Autism and Developmental Disabilities Monitoring (ADDM) Network, an ongoing surveillance system that provides estimates on the prevalence of autism spectrum disorder (ASD), that 1 in 44 children in the U.S. have an autism diagnosis, a 10% increase from its 2018 report...

Still more research shows that many of the most common mental and physical conditions, including allergies and inflammation, may have a common somatic cause: mast cell over-activation. This insight may open unprecedented ways to understand and treat allergies, asthma, arthritis, cardiovascular diseases, psoriasis, dermatitis, cancer, endometriosis, and others such as Parkinson's disease, Alzheimer’s disease, ADHD or autism, chronic fatigue syndrome and Long-COVID syndrome. Discover how mast cell over-activation may drive autoimmune conditions, neuroinflammation, and a cascade of chemical imbalances in our bodies, significantly impacting our emotions and behaviors, and derailing our mind and body wellbeing.

Prof. Theoharis Theoharides, MSc, MPhil, PhD, MD has been invited to present a lecture entitled

SARS-CoV-2 spike protein, neuroinflammation and brain fog

at an all-NIH virtual conference

Unraveling Links Between Chronic Inflammation and Long COVID

Event Website: https://events.cancer.gov/nih/inflammation-long-covid

Registration Link: https://events.cancer.gov/nih/inflammation-long-covid/registration

Hashtags: #NCIEvent, #NCI, #LongCOVID, #LongCOVIDResearch, #LongCOVIDWorkshop, #LongHaulCOVID

DrTheoharides speaks at the 9-2023 NIH workshop on Neurologic Aspects of Long-COVID

SARS-CoV-2 spike protein, Neuroinflammation and Brain Fog

Evidence indicates that post-acute sequelae of COVID-19 (PASC) or Long-COVID, is characterized by physical and mental fatigue that could be prevented or minimized by use of liposomal formulations of luteolin, such as in the novel supplement BrainGain (R) from www.algonot.com.

See the Video

Learn More & Additional COVID Resources

Dr. Theoharides and his colleague Dr. Tsilioni reported for the first time that the Coronavirus Spike protein stimulates human mast cells to secrete proinflammatory molecules via the receptor TLR-4 and not the well-known receptor ACE2.

With thanks for help from Dr. Elizabeth Spaar, we put together these signs of shortness of breath you may look for in case someone is not able to communicate or is nonspeaking:

·     Lethargy or unusual tiredness
·     Panting or loud breathing
·     Sucking in (retraction) at base of throat while inhaling
·     Sucking in (retraction) at the ribs, also during inhale
·     Belly breathing - seeing the stomach extended more than usual on inhale
·     Stomach muscles tensing while trying to push air out
·     Longer time to exhale than inhale
·     Tripod stance (leaning over with hands on knees)
·     Bluish nail beds or lips
·     Change of mental status/confusion

If you develop emergency warning signs for COVID-19 get medical attention immediately. Emergency warning signs include:

·     Difficulty breathing or shortness of breath
·     Persistent pain or pressure in the chest
·     New confusion or inability to arouse
·     Bluish lips or face

More information can be found at the CDC's website

Mast Cell research

Pharmacology is the core of translational research leading to ways of alleviating disease. We study how mast cells are involved in allergy and inflammation. We showed that mast cells are activated by CRH and neurotensin secreted under stress to release inflammatory molecules selectively, including mitochondrial DNA ("innate pathogen") leading to disruption of the gut-blood-brain barriers and to inflammation. We have also shown that the flavonoid luteolin is inhibitory, and a patented liposomal formulation NeuroProtek®, benefits patients with allergies, autism and chronic fatigue syndrome...

Mast cell topics & recent publications

Here you will find over 100 publications from the Theoharides’ Lab relevant to his research in Pharmacology and Drug Development.

Awards & Honors

Awards and honors for Dr. Theoharides.

video presentations

A look into Dr. Theoharides’ lectures or interviews on various topics.

English

Greek

Spanish

Lecture Slides

Follow along copies of slides Dr. Theoharides has lectured with. Some may be used in conjunction with video lecture presentations or guides for research.

Clinical studies

Papers on past and present clinical studies.

Testimonials &
Useful Links

Kind words for Dr. Theoharides and his work.

Donations for Center of Excellence for Neuroinflammation Research
Director: Prof. Theoharis Theoharides, MS, MPhil, PhD, MD
At Nova Southeastern University can be made in the following way:

Checks should be made out to:
Nova Southeastern University and reference
Index No. 337179- INIM Neuro-Inflammation Research
NSU Tax ID #54-1083502

And mailed to:
Nathalie Sloan
Institute for Neuro Immune Medicine
3321 College Avenue
Fort Lauderdale, Fl. 33314

Featured presentation

AUTISM - A Pharmacologist's View.

HealthMeans Lecture - Learn more.

Learn more about T. C. Theoharides, MS, PhD, MD, FAAAAI

New "innate pathogens" discovered by Dr. Theoharides (PDF)

Most Cited scientists

Dr. Theoharides was just included in the top .05% of the most cited scientists in the world recently compiled by ScholarGPS.

Interstitial Cystitis/Bladder Pain Syndrome Symposium, March 11, 2023

• Video

Event Photos

Canadian Allergy & Immunology Today - PDF

Mast Cells in Atopic Diseases - TC Theoharides, MS MPhil MD PhD

top rated expert in Mast cells

Dr. Theoharides is rated the number one world's leading expert on mast cells according to Expertscape.

See Ratings

Expertscape's PubMed-based algorithms placed Dr. Theoharides in the top 1% of scholars writing about Mastocytosis over the past 10 years, a level we label as "Expert." The following was announced on Twitter on Nov 9, 2021:

"During Healthy Skin Month (November 2021), we congratulate
Dr. Theoharis C Theoharides of Tufts University --
Recognized as an Expertscape Expert in Mastocytosis."

Potential Anti-inflammatory Treatment for Autism @ safeMinds

Greek Newspaper Article 2017 (PDF)

Greek Newspaper Article 2016 (PDF)

Groundbreaking Research Links Autism with Histamine, Inflammation and Mast Cell Activation. Read Article

Congratulations to Dr. Theoharides! The book Neuroimmune Pharmacology has recently been published in electronic and print format. Dr. Theoharids contributed to the Autism Spectrum Disorders portion of the book.

•• Dr. Theoharides paper "Neurotensin stimulates NTR3/sortilin and mTOR in human microglia: Potential therapeutic target in autism inhibitable by methoxyluteolin" has published online at www.pnas.org.

•• Dr. Theoharides selected to be included in "Famous Greeks"

•• Article on Dr. Theoharides' work on "BrainFog" in the Greek paper VIMA TIS KYRISKIS-SUNDAY SCIENCE edition (July 17, 2016)

•• Luteolin for mast cells, histamine and brain fog?

•• A wonderful plant supplement has been backed by scientific research as a mast cell stabiliser and antihistamine.

•• Hope For Autism - The National Herald

•• Autism Spectrum Programs at The Boston Conservatory

•• National Psoriasis Foundation - News Articles

Videos

My mystery symptoms and mast cells (documentary)

ARI-Brain Allergy and Autism

Interview with Dr. Theoharides on GREEK NATIONAL TV DIPLI MATIA on Autism and Brain Fog

Interview with Dr. Theoharides on CNN.gr on Brain Inflammation

Radio & Podcast Presentations

How to Make Friends With Your Immune System, the Latest Research on Autism, and Rethinking Antioxidant Supplements with Dr. Theoharis Theoharides. Listen to the Podcast

Interview of Dr. Theoharides by Mary Ann Rousso to The BlockTakRadio/Coffee Klatch/Special Needs Radio on Mast Cell Disorders.

Interview of Dr. Theoharides on intelligent radio by Dr. Hoffman on the benefits of luteolin.

upcoming events

16-18 Mar

MAPS SPRING 2023
Functional & Translational Medicine Conferance MARCH 16-18, 2023 at Charlotte, NC
Event Website

4 Apr

FREE WEBINAR
Mast Cell Over-Activation, and How it Affects our Mind and Body Wellbeing
Thursday, April 4th 1:00 PM EDT | 19:00 (Copenhagen)
Location: Zoon
Send an email to mastcell@neurodiversitet.net about your participation. A Zoom link will be shared in response.

Greek Presentations

• Το σύνδρομο του Long Covid και η εξατομικευμένη προστασία από τον κορονοϊό

• Long Covid Syndrome και εξατομικευμένη προστασία από τον κορονοϊό

• Presentation 01 / PDF Details

Prof. Theoharides' Invited Lectures (2015-17)

• Australia Autism Lecture (April 24, 2015; Melbourne, Australia)
• Boston Conservatory of Music (May 5, 2015; Boston, MA)
• Autism Education Summit (September 26, 2015; Dallas, TX)
• National Autism Association (October 15, 2015; St. Pete, FL)
• Autism Research Institute (December 5, 2015; Boston, MA, 2015)
• Cyprus Pediatric Association (February 14, 2016; Nicosia, CY)
• TARF Think Tank (February 19, 2016; Boston, MA)
• NCIMS (February 27, 2016;Greenboro, NC)
• TACA Massachusetts (March 12, 2016; Watertown MA)
• 11th PanHellenic Conference on Allergy & Clinical Immunology (April 16, 2016; Athens, Greece)
• TACA Webinar (April 25, 2016; 1 pm)
• All Childrens Hospital (April 1, 2016; St. Pete, FL)
• TACA Philadelphia (May 7, 2016; Philadelphia, PA)
• Autism One (May 27, 2016; Chicago, IL)
• Autism One Think Tank (May 28, 2016; Chicago, IL)
• EAAACI (June 7-11, 2017; Vienna, Austria)
• Old North State Medical Society (June 23-25, 2016; Raleigh, NC)
• FASEB Summer Research Conference in the long-running Neuroimmunology series entitled "Translational Neuroimmunology: From Mechanisms to Therapeutics" (July 24-29, 2016; Big Sky, MT)
• 11th Annual USAAA World Autism and Asperger Conference (August 29, 2016; Louisville, KY)
• MAPS Conference (September 9, 2016; Atlanta, GA)
• The Mastocytosis Society (September 15-17, 2016; Orlando, FL)
• International College of Geriatric Psychoneuropharmacology (ICGP) (October 7, 2016; Athens, Greece)
• TACA National Conference (October 22, 2016; Costa Mesa, CA)
• ILADS Annual meeting (November 4, 2016; Philadelphia, PA)
• 37th UMEMPS (Union of Middle-Eastern and Mediterranean Pediatric Societies-Cyprus Pediatric Society (November 6, 2016; Limassol, Cyprus)
• 1st International Conference on Autism (November 22, 2016; Paphos, Cyprus)
• Nashville Support Group Meeting - Saturday, September 16, 2017 10a-4p Hermitage Library, 3700 James Kay Lane, Hermitage, TN 37076 Speaker: Dr. Theoharides, MD
• Brain Fires in Autism: Mast Cells, Microglia and Brain Inflammation - Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM October 2017.
• Stress, Brain Inflammation and Brain Fog in Autism - Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM October 2017
• Bari (Italy), 2nd European Conference of Biomedical Research and Treatments of Autism - Mast cell-microglia connection leading to focal inflammation of the brain in autism Saturday @ 15.40 - Brochure (PDF) November 2017
• Queen Mary University of London, 15:30-15:30-Regulatory systems pathway from stress to disease and possible parallels to periodontal disease Email: a.b.o.gamboa@qmul.ac.uk November 2017
• Queen Mary University of London, 15:30-16:00-Interventions on the immune regulatory systems Email: a.b.o.gamboa@qmul.ac.uk November 2017
• Conway Hall, London, 10:00 am, Brain Fires in Autism: Mast Cells, Microglia and Inflammation of the Brain December 2017
• Conway Hall, London, 10:00 am, Role of Mast Cells in Inflammatory Diseases December 2017

EAAACI=European Academy of Allergy and Clinical Immunology
ILADS=International Lyme and Associated Diseases Society
MAPS=Medical Academy of Pediatrics Se-0pcial Needs
NCIMS=North Carolina Integrative Medical Society
TARF=The Autism Research Foundation
TACA=Think About Curing Autism
ILADS=International Lyme and Associated Diseases Society

dietary supplements

Find useful dietary supplements based upon our work.

Dietary Supplement Advice

Luteolin supplements: All that glitters is not gold (PDF)
Algonot Supplements (PPT)

past event photos

TACA National Conference - October 20 - 22, 2017

research activities

Photos

Websites

www.gentlederm.com
www.brain-gate.org

How to Explain Autism to Children
https://indyschild.com/how-to-explain-autism-to-children/

Creating the Ultimate Sensory Room for Your Toddler
https://localbabysitter.com/creating-the-ultimate-sensory-room-for-your-toddler/