For More Scientific Information on NeuroProtek:
Double-blind, placebo-controlled, cross-over study for the treatment of remitting-relapsing multiple sclerosis. (Principal Investigator: T.C. Theoharides, Ph.D., M.D, Co-PI: S.L. Hauser, M.D. Site: Massachusetts General Hospital, Boston, MA).
Double-blind, placebo-controlled, study for the treatment of interstitial cystitis. (Principal Investigator: T.C. Theoharides, Ph.D., M.D, Co-PI: G.R. Sant, M.D. Site: Clinical Research Center, New England Med. Center).
Double-blind, placebo-controlled, study for the prevention of migraine headaches. (Principal Investigator: T.C. Theoharides, Ph.D., M.D; co-PI: E. Spierings, M.D., Ph.D. Site: Boston, Clinical Research Center, Newton, MA-2004).
Single-blind, open label study of the effect of a flavonoid formulation on niacin-induced flush. (Principal Investigator: T.C. Theoharides, Ph.D., M.D., Co-I: Dimitris Kalogeromitros, Ph.D., M.D. Site: Attikon Hospital, Athens, Greece-2008).
Single-blind, open label study of the effect of a flavonoid formulation, CystoProtek, on interstitial cystitis. (Principal Investigator: T.C. Theoharides, Ph.D., M.D., Co-I: Grannum R. Sant, M.D. Site: Multiple throughout the USA-2008).
Single-blind, open label study of the effect of a flavonoid formulation on niacin-induced flush. (Principal Investigator: T.C. Theoharides, Ph.D., M.D., Co-I: Dimitris Kalogeromitros, Ph.D., M.D. Site: Attikon General Hospital, Athens, Greece-2009).
Open label study of biomarkers in young children with autism. (Principal Investigator: T.C. Theoharides, Ph.D., M.D., Co-Is: Dimitris Kalogeromitros, Ph.D., M.D., Konstantinos Francis, M.D. Site: Attikon General Hospital, Athens, Greece-2009).
Open label study of tolerability and effectiveness of NeuroProtekÒ in autistic children (Principal Investigator: Prof. L. Lykouras . site: Second Department of Psychiatry, Attikon Hospital Athens, Greece-2011)
Double-blind, placebo-controlled, cross-over study of a flavonoid formulation for the treatment of autism. (Principal Investigator: T.C. Theoharides, Ph.D., M.D, Co-PI: Isaac Melamed, M.D. Site:IMMUNOe, Centennial, CO).
Questions & Answers
Q: There are references in Dr Theo's work to Neuroprotek being a liposomal formulation with the olive kernel oil. My understanding of liposomal formulations such as the various lipo-C and lipo-glutathione supplements on the market is that means encasing the particles in tiny spheres of phospholipids. Obviously, olive kernel oil is not a phospholipid. Is there something I'm missing? Or is calling neuroprotek a liposomal formulation just a "loose" description? See for instance, the wikipedia page on liposomes: http://en.wikipedia.org/wiki/Liposome. I wonder what Dr Theo's take is?
A: Olive kernel oil contains many lipids, including phospholipids. Any time you add energy to an oil it assumes the least energy configuration which is a sphere. The more energy you provide, the smaller the microspheres. During this process, the microspheres encapsulate the solutes, in this case the flavonoids. NeuroProtex is prepared by mixing the ingredients with olive kernel oil using a proprietary procedure. Even though the word liposome was originally coined to mean use of synthetic phospholipids, it is used for any type of liposomamal preparation. If the term microsphere is preferable for the public, we can use this instead.
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Autism Parenting Summit
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EAAACI=European Academy of Allergy and Clinical Immunology
ILADS=International Lyme and Associated Diseases Society
MAPS=Medical Academy of Pediatrics Se-0pcial Needs
NCIMS=North Carolina Integrative Medical Society
TARF=The Autism Research Foundation
TACA=Think About Curing Autism
ILADS=International Lyme and Associated Diseases Society
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